Correlation Between Serum Uric Acid Levels In Hypertensive and Normotensive Subjects: A Case–Control Study

Abstract

Background: Hypertension is one of the causative factors of cardiovascular mortality and morbidity in the world. SUA has also been implicated in the pathophysiology of hypertension via renal microvascular injury and dysfunction, oxidation and activation of the renin-angiotensin system. However, the influence and independence of the SUA-hypertension association remains debatable. This study compared the SUA in cases (hypertensive) and controls (normotensive) of adulthood and assessed the correlation of SUA with the blood pressure measures.

Methods: The study was a case control study conducted at RLJH hospital for a span of 3 month duration with 64 participants (32 hypertensive patients & 32 normsotensive control group) above the age of 18 years. The number of participants excluded was as follows: gout; renal failure; malignancy; chemotherapy / radiotherapy; and recent diuretic or alcohol intake. Venous blood (4 ml) was obtained at the time of admission and SUA was measured using Trivedi-Kabasakalian uricase-peroxidase (modified Trinder) assay. Data was analyzed using the SPSS (v22) software using the independent t-tests, the chi-square test and Pearson correlation, with the p value considered significant at p < 0.05....

Results: The mean +- SD SUA of the hypertensive cases (6.89 +- 1.05 mg/dl) was significantly higher than the normotensive controls (5.97 +- 0.98 mg/dl) had a mean of 0.92 (95% 0.45 1.39) diverge below the test value 0.05. The prevalence of hyperuricemia was 43.8 percent and 15.6 percent respectively in the hypertensive and in the control patients (p = 0.013). SUA also had positive significant correlations with systolic BP (0,72; P < 0;001) as well as with diastolic BP (0,68; P < 0;001). In multivariate logistic regression on the age, sex, body mass index, and serum creatinine, a difference of 1 mg/dL of each of the following variables was an interchangeable predictor of hypertension (adjusted OR = 2.31; 95% CI 1.22 -4.39; p = 0.011).

Conclusion: The serum uric acid level was also high in hypertensive adults and positively correlated with systolic and diastolic BP. A high SUA was independent predictor of hypertension status with the possible use of this in an indicator of CVD reliable quality was also consistent. Hypothesis: Studies need to be done in large numbers and prospectively to look for interaction and efficacy of urate-lowering intervention on BP control...